Acta1 (GeneName), Actin, alpha skeletal muscle (ProteinName), ACTS_MOUSE.
Mouse Acta1/ Actin, alpha skeletal muscle ELISA Kit
Natural and recombinant mouse Actin, alpha skeletal muscle
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
MCDEDETTAL | VCDNGSGLVK | AGFAGDDAPR | AVFPSIVGRP | RHQGVMVGMG |
QKDSYVGDEA | QSKRGILTLK | YPIEHGIITN | WDDMEKIWHH | TFYNELRVAP |
EEHPTLLTEA | PLNPKANREK | MTQIMFETFN | VPAMYVAIQA | VLSLYASGRT |
TGIVLDSGDG | VTHNVPIYEG | YALPHAIMRL | DLAGRDLTDY | LMKILTERGY |
SFVTTAEREI | VRDIKEKLCY | VALDFENEMA | TAASSSSLEK | SYELPDGQVI |
TIGNERFRCP | ETLFQPSFIG | MESAGIHETT | YNSIMKCDID | IRKDLYANNV |
MSGGTTMYPG | IADRMQKEIT | ALAPSTMKIK | IIAPPERKYS | VWIGGSILAS |
LSTFQQMWIT | KQEYDEAGPS | IVHRKCF
This product has not yet been referenced specifically in any publications.
"The pathogenesis of ACTA1-related congenital fiber type disproportion."
"The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."
"Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred."
"Actin mutations are one cause of congenital fibre type disproportion."
"Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1)."
"Heterogeneity of nemaline myopathy cases with skeletal muscle alpha-actin gene mutations."
"Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms."
"Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene."
"Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene."
"Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy."
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