ACTA1 (GeneName), Actin, alpha skeletal muscle (ProteinName), ACTS_BOVIN.
Product Name:
Bovine ACTA1/ Actin, alpha skeletal muscle ELISA Kit
Cat.#:
E1634b
Brand:
EIAab®
Regulatory Status:
Alternative:
Alpha-actin-1, ACTA
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.101ng/mL
Specificity:
Natural and recombinant bovine Actin, alpha skeletal muscle
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular Location:
Cytoplasm
Cytoskeleton
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[2].
"The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."
[3].
"Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred."
[5].
"Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1)."
[6].
"Heterogeneity of nemaline myopathy cases with skeletal muscle alpha-actin gene mutations."
[7].
"Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms."
[8].
"Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene."
[9].
"Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene."
[10].
"Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy."
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