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ACTA1 (GeneName), Actin, alpha skeletal muscle (ProteinName), ACTS_BOVIN.
Product Name:

Bovine ACTA1/ Actin, alpha skeletal muscle ELISA Kit

Cat.#:

E1634b

Brand:
EIAab®
Regulatory Status:
Alternative:

Alpha-actin-1, ACTA

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.101ng/mL
Specificity:
Natural and recombinant bovine Actin, alpha skeletal muscle
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Bovine ACTA1 ELISA Kit
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Bovine ACTA1 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.


Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


Subcellular Location:
Cytoplasm Cytoskeleton


This product has not yet been referenced specifically in any publications.

[1].
"The pathogenesis of ACTA1-related congenital fiber type disproportion."

[2].
"The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."

[3].
"Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred."

[4].
"Actin mutations are one cause of congenital fibre type disproportion."

[5].
"Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1)."

[6].
"Heterogeneity of nemaline myopathy cases with skeletal muscle alpha-actin gene mutations."

[7].
"Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms."

[8].
"Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene."

[9].
"Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene."

[10].
"Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy."
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