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首页  >  酶联免疫试剂盒  >  Rat Actn4 ELISA Kit
Actn4 (基因名), Alpha-actinin-4 (蛋白名), ACTN4_RAT.
产品名称:

Rat Actn4/ Alpha-actinin-4 ELISA Kit
α辅肌动蛋白4

货号:

E1460r

商标:
EIAab®
监管等级:
别名:

Non-muscle alpha-actinin 4

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
39.14pg/mL
特异性:
Natural and recombinant rat Alpha-actinin-4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Epigenetics
Rat Actn4 ELISA Kit
规格 & 价格: cart
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Rat Actn4 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Homodimer; antiparallel (By similarity). Interacts with BAIAP1 (By similarity). Interacts with MICALL2 (preferentially in opened conformation); stimulated by RAB13 activation (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Binds TRIM3 at the N-terminus. Interacts with PDLIM2. Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1. Interacts with PPARG and RARA (By similarity). Binds to VCL; this interaction triggers VCL conformational changes.


功能:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.


亚细胞位置:
Nucleus Cytoplasm Cell junction Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers.


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