ACTN4 (GeneName), Alpha-actinin-4 (ProteinName), ACTN4_CHICK.
Product Name:
Chicken ACTN4/ Alpha-actinin-4 ELISA Kit
Cat.#:
E1460c
Brand:
EIAab®
Regulatory Status:
Alternative:
Non-muscle alpha-actinin 4
Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Alpha-actinin-4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Epigenetics
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Homodimer; antiparallel. Component of the CART complex. May interact with nuclear receptors.
Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors.
Subcellular Location:
Nucleus
Cytoplasm
Cell junction
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis."
[2].
"ACTN4 gene mutations and single nucleotide polymorphisms in idiopathic focal segmental glomerulosclerosis."
[3].
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."
[4].
"Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis."
[5].
"Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism."
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