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ACTN4 (GeneName), Alpha-actinin-4 (ProteinName), ACTN4_CHICK.
Product Name:

Chicken ACTN4/ Alpha-actinin-4 ELISA Kit

Cat.#:

E1460c

Brand:
EIAab®
Regulatory Status:
Alternative:

Non-muscle alpha-actinin 4

Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Alpha-actinin-4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Epigenetics
Chicken ACTN4 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homodimer; antiparallel. Component of the CART complex. May interact with nuclear receptors.


Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors.


Subcellular Location:
Nucleus Cytoplasm Cell junction


This product has not yet been referenced specifically in any publications.

[1].
"Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis."

[2].
"ACTN4 gene mutations and single nucleotide polymorphisms in idiopathic focal segmental glomerulosclerosis."

[3].
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."

[4].
"Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis."

[5].
"Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism."
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