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ACTN2 (GeneName), Alpha-actinin-2 (ProteinName), ACTN2_BOVIN.
Product Name:

Bovine ACTN2/ Alpha-actinin-2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein

Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Alpha-actinin-2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
Bovine ACTN2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST (via N-terminus). Interacts with PARVB. Interacts with SYNPO2.


Function:
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.


Subcellular Location:
Cytoplasm Myofibril Sarcomere Z line Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.


This product has not yet been referenced specifically in any publications.

[1].
"Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11."

[2].
"Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis."

[3].
"alpha-actinin-3 and performance."

[4].
"ZASP: a new Z-band alternatively spliced PDZ-motif protein."

[5].
"Fine mapping and genomic structure of ACTN2, the human gene coding for the sarcomeric isoform of alpha-actinin-2, expressed in skeletal and cardiac muscle."

[6].
"Novel α-actinin 2 variant associated with familial hypertrophic cardiomyopathy and juvenile atrial arrhythmias: a massively parallel sequencing study."

[7].
"Exome sequencing identifies a mutation in the ACTN2 gene in a family with idiopathic ventricular fibrillation, left ventricular noncompaction, and sudden death."

[8].
"F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo."

[9].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

[10].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
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