Home > ELISA Kit > Mouse Actn1 ELISA Kit

Actn1 (GeneName), Alpha-actinin-1 (ProteinName), ACTN1_MOUSE.

Product Name:

Mouse Actn1/ Alpha-actinin-1 ELISA Kit

Cat.#:

E0376m

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Alpha-actinin cytoskeletal isoform, F-actin cross-linking protein, Non-muscle alpha-actinin-1

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.156-10ng/mL

Sensitivity:

0.078ng/mL

Specificity:

Natural and recombinant mouse Alpha-actinin-1

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

Cancer

Size & Price: Sign In.

Attention

Mouse Actn1 ELISA Kit

Email *

Message *

Please Sign In.

Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
Feedback Wall (0)

General Annotation

Sub Unit:

Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP (By similarity). Interacts with DNM2 and CTTN (By similarity). Interacts with PSD. Interacts with MICALL2.

Function:

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Subcellular Location:

Cytoplasm Cytoskeleton Cytoplasm Myofibril Sarcomere Z line Cell membrane Cell junction Cell projection Ruffle Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures.

Database link

UniGene:

Mm.253564

SMR:

Q7TPR4

STRING:

10090.ENSMUSP00000021554

KEGG:

mmu:109711

Pfam:

PF00307

Uniprot:

Q7TPR4

Related Product

Human ACTN1 ELISA Kit

Rat Actn1 ELISA Kit

Bovine ACTN1 ELISA Kit

Chicken ACTN1 ELISA Kit

Human ACTN1 CLIA Kit

Sequence length:

892

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

892:

ELPPDQAEYC | IARMAPYAGP | DSVPGALDYM | SFSTALYGES | DL

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring."

(PMID: 16464232)

[2].

"Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene."

(PMID: 2349951)

[3].

"A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family."

(PMID: 24069336)

[4].

"ACTN1 mutations cause congenital macrothrombocytopenia."

(PMID: 23434115)

[5].

"Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells."

(PMID: 20156433)

[6].

"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

(PMID: 20634891)

[7].

"Genome-wide and candidate gene association study of cigarette smoking behaviors."

(PMID: 19247474)

[8].

"Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology."

(PMID: 20037648)

[9].

"Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding."

(PMID: 19750481)

[10].

"Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation."