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Mc2r (GeneName), Adrenocorticotropic hormone receptor (ProteinName), ACTHR_MOUSE.
Product Name:

Mouse Mc2r/ Adrenocorticotropic hormone receptor ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

ACTH receptor, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, Acthr

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Adrenocorticotropic hormone receptor
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
Mouse Mc2r ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).


Function:
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency."

[2].
"Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2."

[3].
"Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms."

[4].
"Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction."

[5].
"ACTH receptor promoter polymorphism associates with severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children."

[6].
"Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."

[7].
"Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH."

[8].
"Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay."

[9].
"Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene."

[10].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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