Mc2r (GeneName), Adrenocorticotropic hormone receptor (ProteinName), ACTHR_MOUSE.
Mouse Mc2r/ Adrenocorticotropic hormone receptor ELISA Kit
ACTH receptor, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, Acthr
Natural and recombinant mouse Adrenocorticotropic hormone receptor
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Cell membrane Multi-pass membrane protein
MKHIINSYEH | TNDTARNNSD | CPDVVLPEEI | FFTISVIGIL | ENLIVLLAVI |
KNKNLQSPMY | FFICSLAISD | MLGSLYKILE | NILIMFRNMG | YLKPRGSFES |
TADDIIDCMF | ILSLLGSIFS | LSVIAADRYI | TIFHALQYHS | IVTMRRTIIT |
LTIIWMFCTG | SGITMVIFSH | HIPTVLTFTS | LFPLMLVFIL | CLYIHMFLLA |
RSHARKISTL | PRTNMKGAMT | LTILLGVFIF | CWAPFVLHVL | LMTFCPNNPY |
CVCYMSLFQV | NGMLIMCNAV | IDPFIYAFRS | PELRDAFKRM | LFCNRY
This product has not yet been referenced specifically in any publications.
"Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency."
"Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2."
"Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms."
"Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction."
"ACTH receptor promoter polymorphism associates with severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children."
"Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."
"Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH."
"Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay."
"Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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