MC2R (GeneName), Adrenocorticotropic hormone receptor (ProteinName), ACTHR_BOVIN.
Product Name:
Bovine MC2R/ Adrenocorticotropic hormone receptor ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACTH receptor, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Adrenocorticotropic hormone receptor
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
Function:
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency."
[2].
"Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2."
[3].
"Genetic polymorphisms of MC2R gene associated with responsiveness to adrenocorticotropic hormone therapy in infantile spasms."
[4].
"Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction."
[5].
"ACTH receptor promoter polymorphism associates with severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children."
[6].
"Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."
[7].
"Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH."
[8].
"Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay."
[9].
"Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene."
[10].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
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