ACTB (基因名), Actin, cytoplasmic 1 (蛋白名), ACTB_HORSE.
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM. Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain). Interacts with TBC1D21.
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Cytoplasm Cytoskeleton Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
MDDDIAALVV | DNGSGMCKAG | FAGDDAPRAV | FPSIVGRPRH | QGVMVGMGQK |
DSYVGDEAQS | KRGILTLKYP | IEHGIVTNWD | DMEKIWHHTF | YNELRVAPEE |
HPVLLTEAPL | NPKANREKMT | QIMFETFNTP | AMYVAIQAVL | SLYASGRTTG |
IVMDSGDGVT | HTVPIYEGYA | LPHAILRLDL | AGRDLTDYLM | KILTERGYSF |
TTTAEREIVR | DIKEKLCYVA | LDFEQEMATA | ASSSSLEKSY | ELPDGQVITI |
GNERFRCPEA | LFQPSFLGME | SCGIHETTFN | SIMKCDVDIR | KDLYANTVLS |
GGTTMYPGIA | DRMQKEITAL | APSTMKIKII | APPERKYSVW | IGGSILASLS |
TFQQMWISKQ | EYDESGPSIV | HRKCF
"A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma."
"De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome."
"Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes."
"Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition."
"[Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer]."
"Molecular composition of IMP1 ribonucleoprotein granules."
"HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration."
"A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12)."
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