ACSM1 (GeneName), Acyl-coenzyme A synthetase ACSM1, mitochondrial (ProteinName), ACSM1_BOVIN.
Product Name:
Bovine ACSM1/ Acyl-coenzyme A synthetase ACSM1, mitochondrial ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acyl-CoA synthetase medium-chain family member 1, BUCS1, LAE, MACS1, Benzoate--CoA ligase, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, Lipoate-activating enzyme, Middle-chain acyl-CoA synthetase 1, XL-III, Xenobiotic/medium-chain fatty acid:CoA ligase XL-3, XM-ligase 3
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Acyl-coenzyme A synthetase ACSM1, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Monomer.
Function:
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754).
Subcellular Location:
Mitochondrion matrix
Mitochondrion
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product."
[2].
"Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension."
[3].
"Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort."
[4].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
[5].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[6].
"Genomewide association for schizophrenia in the CATIE study: results of stage 1."
[7].
"15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma."
[8].
"An acyl-CoA synthetase gene family in chromosome 16p12 may contribute to multiple risk factors."
[9].
"Architecture of the human interactome defines protein communities and disease networks."
[10].
"Genetic association of ACSM1 variation with schizophrenia and major depressive disorder in the Han Chinese population."
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