ACSM1 (GeneName), Acyl-coenzyme A synthetase ACSM1, mitochondrial (ProteinName), ACSM1_BOVIN.
Bovine ACSM1/ Acyl-coenzyme A synthetase ACSM1, mitochondrial ELISA Kit
Acyl-CoA synthetase medium-chain family member 1, BUCS1, LAE, MACS1, Benzoate--CoA ligase, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, Lipoate-activating enzyme, Middle-chain acyl-CoA synthetase 1, XL-III, Xenobiotic/medium-chain fatty acid:CoA ligase XL-3, XM-ligase 3
Natural and recombinant bovine Acyl-coenzyme A synthetase ACSM1, mitochondrial
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754).
Mitochondrion matrix Mitochondrion
MQRLMKFRVL | WGIHMSCPGF | HHAPQHLRCR | SLSGAGTLRW | NDYDRPEEFN |
FASDVLDHWT | QMEKEGKRS | PNPALWWVND | QGDEVKWSFR | EMTDLTCRTA |
NVLTQTCGLQ | TGDRLALILP | R VPEWWLVC | VGCIRTGIIF | MPGTTQMKAK |
DILYRLQVSG | AKAIVTTDTL | APEVESVAPE | CP SLKTKLL | VSDHSREGWL |
DFRSLVKSAS | PDHICIKSKT | LDPMAIFFTS | GTTGFPKMAK | HSH GFALRS |
YFPACRKLLQ | LKMSDVFWCL | SDTGWILAAL | GSLLEPWTAG | STVFAHHLPQ |
FDPK VIIET | FFKYPITQCL | AAPSVYRMIL | QQNYTSLRFP | TLEHCCTGGE |
ALLPEEQEQW | KRQTG VLLY | QAYGQSETGI | SCGTLRGMKI | KPGSMGKAIP |
PFDIQIIDDK | GNIQPPNTEG | NIGIRI KPT | RPIGLFMYYE | NNPEKTAEVE |
CGDFYNTGDR | ATIDEEGYFW | FLGRSDDVIN | ASGYRVG PA | EVENALAEHP |
AVAESAVVSS | PDPVRGEVVK | AFIVLNPEFS | SRDPGELTKE | LQQHVKSV T |
APYKYPRKVE | FVSELPKTIT | GKIKRSELRK | KEFGQK
This product has not yet been referenced specifically in any publications.
"Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product."
"Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension."
"Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
"Genomewide association for schizophrenia in the CATIE study: results of stage 1."
"15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma."
"An acyl-CoA synthetase gene family in chromosome 16p12 may contribute to multiple risk factors."
"Architecture of the human interactome defines protein communities and disease networks."
"Genetic association of ACSM1 variation with schizophrenia and major depressive disorder in the Han Chinese population."
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