Acsl5 (GeneName), Long-chain-fatty-acid--CoA ligase 5 (ProteinName), ACSL5_RAT.
Product Name:
Rat Acsl5/ Long-chain-fatty-acid--CoA ligase 5 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acs5, Facl5, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Long-chain-fatty-acid--CoA ligase 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.
Subcellular Location:
Mitochondrion
Endoplasmic reticulum
Mitochondrion outer membrane
Single-pass type III membrane protein
Endoplasmic reticulum membrane
Single-pass type III membrane protein
Cell membrane
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas."
[2].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
[3].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[4].
"Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."
[5].
"Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response."
[7].
"Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5."
[8].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
[9].
"Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5."
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