Acsl5 (GeneName), Long-chain-fatty-acid--CoA ligase 5 (ProteinName), ACSL5_RAT.
Rat Acsl5/ Long-chain-fatty-acid--CoA ligase 5 ELISA Kit
Acs5, Facl5, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5
Natural and recombinant rat Long-chain-fatty-acid--CoA ligase 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.
Mitochondrion Endoplasmic reticulum Mitochondrion outer membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein Cell membrane
MLFIFNFLFS | PLPTPALICL | LTFGTAIFLW | LINRPQPVLP | LIDLDNQSVG |
IEGGARRGAF | QKNNDLILY | YFSDAKTLYE | VFQRGLAVSD | NGPCLGYRKP |
NQPYKWISYK | QVSDRAEYLG | S CLLHKGYK | PSQDQFIGIF | AQNRPEWVIS |
ELACYTYSMV | AVPLYDTLGA | EAIIYVINRA | DI SVVICDT | PQKATMLIEN |
VEKDLTPGLK | TVILMDPFDD | DLMKRGEKCG | IEMLSLHDAE | NLG KENFKK |
PMPPNPEDLS | VICFTSGTTG | DPKGAMLTHQ | NIVSNMAAFL | KFLEPIFQPT |
PEDV TISYL | PLAHMFERLV | QGVIFSCGGK | IGFFQGDIRL | LPDDMKALKP |
TVFPTVPRLL | NRVYD KVQN | EAKTPLKKFL | LNLAIISKFN | EVRNGIIRRN |
SLWDKLVFSK | IQSSLGGKVR | LMITGA API | STPVLTFFRA | AMGCWVFEAY |
GQTECTAGCS | ITSPGDWTAG | HVGTPVSCNF | VKLEDVA DM | NYFSVNNEGE |
ICIKGNNVFK | GYLKDPEKTQ | EVLDKDGWLH | TGDIGRWLPN | GTLKIIDR K |
KNIFKLAQGE | YIAPEKIENV | YSRSRPILQV | FVHGESLRSF | LIGVVVPDPE |
SLPSFAAKI | GVKGSFEELC | QNQCVKKAIL | EDLQKVGKEG | GLKSFEQVKS |
IFVHPEPFSI | ENGLLTPTLK | AKRVELAKF | FQTQIKSLYE | SIEE
This product has not yet been referenced specifically in any publications.
"Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
"Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."
"Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response."
"Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing."
"Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5."
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
"Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5."
"The DNA sequence and comparative analysis of human chromosome 10."
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