ACSL5 (GeneName), Long-chain-fatty-acid--CoA ligase 5 (ProteinName), ACSL5_HUMAN.
Product Name:
Human ACSL5/ Long-chain-fatty-acid--CoA ligase 5 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACS5, FACL5, UNQ633/PRO1250, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5
Detection Method:
ELISA
Specificity:
Natural and recombinant human Long-chain-fatty-acid--CoA ligase 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Subcellular Location:
Mitochondrion
Endoplasmic reticulum
Mitochondrion outer membrane
Single-pass type III membrane protein
Endoplasmic reticulum membrane
Single-pass type III membrane protein
Cell membrane
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas."
[2].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
[3].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[4].
"Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."
[5].
"Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response."
[7].
"Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5."
[8].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
[9].
"Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5."
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