ACSL5 (GeneName), Long-chain-fatty-acid--CoA ligase 5 (ProteinName), ACSL5_HUMAN.
Human ACSL5/ Long-chain-fatty-acid--CoA ligase 5 ELISA Kit
ACS5, FACL5, UNQ633/PRO1250, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 5, LACS 5
Natural and recombinant human Long-chain-fatty-acid--CoA ligase 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Mitochondrion Endoplasmic reticulum Mitochondrion outer membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein Cell membrane
MLFIFNFLFS | PLPTPALICI | LTFGAAIFLW | LITRPQPVLP | LLDLNNQSVG |
IEGGARKGVS | QKNNDLTSC | CFSDAKTMYE | VFQRGLAVSD | NGPCLGYRKP |
NQPYRWLSYK | QVSDRAEYLG | S CLLHKGYK | SSPDQFVGIF | AQNRPEWIIS |
ELACYTYSMV | AVPLYDTLGP | EAIVHIVNKA | DI AMVICDT | PQKALVLIGN |
VEKGFTPSLK | VIILMDPFDD | DLKQRGEKSG | IEILSLYDAE | NLG KEHFRK |
PVPPSPEDLS | VICFTSGTTG | DPKGAMITHQ | NIVSNAAAFL | KCVEHAYEPT |
PDDV AISYL | PLAHMFERIV | QAVVYSCGAR | VGFFQGDIRL | LADDMKTLKP |
TLFPAVPRLL | NRIYD KVQN | EAKTPLKKFL | LKLAVSSKFK | ELQKGIIRHD |
SFWDKLIFAK | IQDSLGGRVR | VIVTGA APM | STSVMTFFRA | AMGCQVYEAY |
GQTECTGGCT | FTLPGDWTSG | HVGVPLACNY | VKLEDVA DM | NYFTVNNEGE |
VCIKGTNVFK | GYLKDPEKTQ | EALDSDGWLH | TGDIGRWLPN | GTLKIIDR K |
KNIFKLAQGE | YIAPEKIENI | YNRSQPVLQI | FVHGESLRSS | LVGVVVPDTD |
VLPSFAAKL | GVKGSFEELC | QNQVVREAIL | EDLQKIGKES | GLKTFEQVKA |
IFLHPEPFSI | ENGLLTPTLK | AKRGELSKY | FRTQIDSLYE | HIQD
This product has not yet been referenced specifically in any publications.
"Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
"Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."
"Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response."
"Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing."
"Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5."
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."
"Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5."
"The DNA sequence and comparative analysis of human chromosome 10."
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