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Acsl4 (GeneName), Long-chain-fatty-acid--CoA ligase 4 (ProteinName), ACSL4_RAT.
Product Name:

Rat Acsl4/ Long-chain-fatty-acid--CoA ligase 4 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acs4, Facl4, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 4, LACS 4

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Long-chain-fatty-acid--CoA ligase 4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
Rat Acsl4 ELISA Kit
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Rat Acsl4 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804, PubMed:23766516, PubMed:9096315). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:9096315). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET (PubMed:23766516). Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (PubMed:23766516). Modulates prostaglandin E2 secretion (By similarity).


Subcellular Location:
Mitochondrion outer membrane Single-pass type III membrane protein Peroxisome membrane Single-pass type III membrane protein Microsome membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein Cell membrane


This product has not yet been referenced specifically in any publications.

[1].
"Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema."

[2].
"FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation."

[3].
"Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression."

[4].
"No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China."

[5].
"Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24."

[6].
"FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation."

[7].
"Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)."

[8].
"The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells."

[9].
"Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells."

[10].
"Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies."
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