ACSL4 (GeneName), Long-chain-fatty-acid--CoA ligase 4 (ProteinName), ACSL4_HUMAN.
Product Name:
Human ACSL4/ Long-chain-fatty-acid--CoA ligase 4 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
ACS4, FACL4, LACS4, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 4, LACS 4
Detection Method:
ELISA
Specificity:
Natural and recombinant human Long-chain-fatty-acid--CoA ligase 4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).
Subcellular Location:
Mitochondrion outer membrane
Single-pass type III membrane protein
Peroxisome membrane
Single-pass type III membrane protein
Microsome membrane
Single-pass type III membrane protein
Endoplasmic reticulum membrane
Single-pass type III membrane protein
Cell membrane
This product has not yet been referenced specifically in any publications.
[1].
"Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema."
[2].
"FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation."
[3].
"Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression."
[4].
"No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China."
[5].
"Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24."
[6].
"FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation."
[7].
"Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)."
[8].
"The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells."
[9].
"Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells."
[10].
"Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies."
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