Home > ELISA Kit > Human ACSL4 ELISA Kit

ACSL4 (GeneName), Long-chain-fatty-acid--CoA ligase 4 (ProteinName), ACSL4_HUMAN.

Product Name:

Human ACSL4/ Long-chain-fatty-acid--CoA ligase 4 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

ACS4, FACL4, LACS4, Arachidonate--CoA ligase, Long-chain acyl-CoA synthetase 4, LACS 4

Detection Method:

ELISA

Specificity:

Natural and recombinant human Long-chain-fatty-acid--CoA ligase 4

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Cardiovascular

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Human ACSL4 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

N/A

Function:

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).

Subcellular Location:

Mitochondrion outer membrane Single-pass type III membrane protein Peroxisome membrane Single-pass type III membrane protein Microsome membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein Cell membrane

Database link

UniGene:

Hs.268785

STRING:

9606.ENSP00000339787

KEGG:

hsa:2182

MIM:

300157

Pfam:

PF00501

Uniprot:

O60488

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Sequence length:

711

Sequence:

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722:

KLKRKELRNH | YLKDIERMYG | GK

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema."

(PMID: 15108178)

[2].

"FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation."

(PMID: 9480748)

[3].

"Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression."

(PMID: 19346733)

[4].

"No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China."

(PMID: 18614287)

[5].

"Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24."

(PMID: 12949969)

[6].

"FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation."

(PMID: 11889465)

[7].

"Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)."

(PMID: 9598324)

[8].

"The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells."