ACSF3 (GeneName), Malonate--CoA ligase ACSF3, mitochondrial (ProteinName), ACSF3_HUMAN.
Product Name:
Human ACSF3/ Malonate--CoA ligase ACSF3, mitochondrial ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
PSEC0197, 6.2.1.n3, Acyl-CoA synthetase family member 3
Detection Method:
ELISA
Specificity:
Natural and recombinant human Malonate--CoA ligase ACSF3, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21846720, PubMed:21841779). May have some preference toward very-long-chain substrates (PubMed:17762044).
Subcellular Location:
Mitochondrion
Database link
UniGene:
SMR:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome."
[2].
"Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis."
[3].
"Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria."
[4].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[5].
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
[7].
"The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency."
[8].
"Architecture of the human interactome defines protein communities and disease networks."
[9].
"Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing."
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