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ACSS1 (GeneName), Acetyl-coenzyme A synthetase 2-like, mitochondrial (ProteinName), ACS2L_HUMAN.
Product Name:

Human ACSS1/ Acetyl-coenzyme A synthetase 2-like, mitochondrial ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, AceCS2, Acyl-CoA synthetase short-chain family member 1, ACAS2L, KIAA1846, Propionate--CoA ligase

Detection Method:
ELISA
Specificity:
Natural and recombinant human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACSS1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with SIRT3.


Function:
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity).


Subcellular Location:
Mitochondrion matrix


This product has not yet been referenced specifically in any publications.

[1].
"Crystal structures of human SIRT3 displaying substrate-induced conformational changes."

[2].
"Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2."

[3].
"Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals."

[4].
"Association of genetic variants with hemorrhagic stroke in Japanese individuals."

[5].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[6].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[7].
"The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma."

[8].
"Association of gene polymorphisms with chronic kidney disease in Japanese individuals."

[9].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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