Acox1 (GeneName), Peroxisomal acyl-coenzyme A oxidase 1 (ProteinName), ACOX1_RAT.
Rat Acox1/ Peroxisomal acyl-coenzyme A oxidase 1 ELISA Kit
AOX, Palmitoyl-CoA oxidase, Acox
Natural and recombinant rat Peroxisomal acyl-coenzyme A oxidase 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage.
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 1 shows optimum activity with a chain length of 10 carbons while isoform 2 exhibits optimum activity with 14 carbons.
MNPDLRKERA | SATFNPELIT | HILDGSPENT | RRRREIENLI | LNDPDFQHED |
YNFLTRSQRY | EVAVKKSATM | VKKMREYGIS | DPEEIMWFKK | LYLANFVEPV |
GLNYSMFIPT | LLNQGTTAQQ | EKWMRPSQEL | QIIGTYAQTE | MGHGTHLRGL |
ETTATYDPKT | QEFILNSPTV | TSIKWWPGGL | GKTSNHAIVL | AQLITQGECY |
GLHAFVVPIR | EIGTHKPLPG | ITVGDIGPKF | GYEEMDNGYL | KMDNYRIPRE |
NMLMKYAQVK | PDGTYVKPLS | NKLTYGTMVF | VRSFLVGNAA | QSLSKACTIA |
IRYSAVRRQS | EIKQSEPEPQ | ILDFQTQQYK | LFPLLATAYA | FHFVGRYMKE |
TYLRINESIG | QGDLSELPEL | HALTAGLKAF | TTWTANAGIE | ECRMACGGHG |
YSHSSGIPNI | YVTFTPACTF | EGENTVMMLQ | TARFLMKIYD | QVRSGKLVGG |
MVSYLNDLPS | QRIQPQQVAV | WPTMVDINSL | EGLTEAYKLR | AARLVEIAAK |
NLQTHVSHRK | SKEVAWNLTS | VDLVRASEAH | CHYVVVKVFS | DKLPKIQDKA |
VQAVLRNLCL | LYSLYGISQK | GGDFLEGSII | TGAQLSQVNA | RILELLTLIR |
PNAVALVDAF | DFKDMTLGSV | LGRYDGNVYE | NLFEWAKKSP | LNKTEVHESY |
HKHLKPLQSK | L
This product has not yet been referenced specifically in any publications.
"Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization."
"Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]."
"Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency."
"Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene."
"Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells."
"Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase."
"Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes."
"Peroxisomal acyl-CoA-oxidase deficiency: two new cases."
"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations."
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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