ACOX1 (GeneName), Peroxisomal acyl-coenzyme A oxidase 1 (ProteinName), ACOX1_HUMAN.
Human ACOX1/ Peroxisomal acyl-coenzyme A oxidase 1 ELISA Kit
AOX, Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidase, SCOX, ACOX
Natural and recombinant human Peroxisomal acyl-coenzyme A oxidase 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
MNPDLRRERD | SASFNPELLT | HILDGSPEKT | RRRREIENMI | LNDPDFQHED |
LNFLTRSQRY | EVAVRKSAIM | VKKMREFGIA | DPDEIMWFKK | LHLVNFVEPV |
GLNYSMFIPT | LLNQGTTAQK | EKWLLSSKGL | QIIGTYAQTE | MGHGTHLRGL |
ETTATYDPET | QEFILNSPTV | TSIKWWPGGL | GKTSNHAIVL | AQLITKGKCY |
GLHAFIVPIR | EIGTHKPLPG | ITVGDIGPKF | GYDEIDNGYL | KMDNHRIPRE |
NMLMKYAQVK | PDGTYVKPLS | NKLTYGTMVF | VRSFLVGEAA | RALSKACTIA |
IRYSAVRHQS | EIKPGEPEPQ | ILDFQTQQYK | LFPLLATAYA | FQFVGAYMKE |
TYHRINEGIG | QGDLSELPEL | HALTAGLKAF | TSWTANTGIE | ACRMACGGHG |
YSHCSGLPNI | YVNFTPSCTF | EGENTVMMLQ | TARFLMKSYD | QVHSGKLVCG |
MVSYLNDLPS | QRIQPQQVAV | WPTMVDINSP | ESLTEAYKLR | AARLVEIAAK |
NLQKEVIHRK | SKEVAWNLTS | VDLVRASEAH | CHYVVVKLFS | EKLLKIQDKA |
IQAVLRSLCL | LYSLYGISQN | AGDFLQGSIM | TEPQITQVNQ | RVKELLTLIR |
SDAVALVDAF | DFQDVTLGSV | LGRYDGNVYE | NLFEWAKNSP | LNKAEVHESY |
This product has not yet been referenced specifically in any publications.
"Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization."
"Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]."
"Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency."
"Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene."
"Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells."
"Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase."
"Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes."
"Peroxisomal acyl-CoA-oxidase deficiency: two new cases."
"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations."
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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