ACOT8 (GeneName), Acyl-coenzyme A thioesterase 8 (ProteinName), ACOT8_HUMAN.
Product Name:
Human ACOT8/ Acyl-coenzyme A thioesterase 8 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, ACTEIII, PTE1, Peroxisomal acyl-CoA thioesterase 2, PTE-2
Detection Method:
ELISA
Specificity:
Natural and recombinant human Acyl-coenzyme A thioesterase 8
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
(Microbial infection) Interacts with human immunodeficiency virus (HIV-1) Nef (via middle region); this interaction enhances ACOT8 Acyl-CoA thioesterase activity and occurs in a Nef myristoylation-independent manner (PubMed:9299485). According to a second report, the interaction with HIV-1 Nef occurs in a Nef myristoylation-independent manner but does not enhance ACOT8 Acyl-CoA thioesterase activity (PubMed:9153233).
Function:
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).
Subcellular Location:
Peroxisome matrix
Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded.
This product has not yet been referenced specifically in any publications.
[2].
"Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation."
[3].
"A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef."
[4].
"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."
[6].
"The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes."
[7].
"Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis."
[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[9].
"The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism."
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