Home > ELISA Kit > Human ACOT8 ELISA Kit

ACOT8 (GeneName), Acyl-coenzyme A thioesterase 8 (ProteinName), ACOT8_HUMAN.

Product Name:

Human ACOT8/ Acyl-coenzyme A thioesterase 8 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, Peroxisomal acyl-coenzyme A thioester hydrolase 1, PTE-1, Peroxisomal long-chain acyl-CoA thioesterase 1, Thioesterase II, hACTE-III, ACTEIII, PTE1, Peroxisomal acyl-CoA thioesterase 2, PTE-2

Detection Method:

ELISA

Specificity:

Natural and recombinant human Acyl-coenzyme A thioesterase 8

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Cardiovascular

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Human ACOT8 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

(Microbial infection) Interacts with human immunodeficiency virus (HIV-1) Nef (via middle region); this interaction enhances ACOT8 Acyl-CoA thioesterase activity and occurs in a Nef myristoylation-independent manner (PubMed:9299485). According to a second report, the interaction with HIV-1 Nef occurs in a Nef myristoylation-independent manner but does not enhance ACOT8 Acyl-CoA thioesterase activity (PubMed:9153233).

Function:

(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).

Subcellular Location:

Peroxisome matrix Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded.

Database link

UniGene:

Hs.444776

SMR:

O14734

STRING:

9606.ENSP00000217455

KEGG:

hsa:10005

MIM:

608123

Uniprot:

O14734

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Sequence length:

319

Sequence:

50:

100:

150:

200:

250:

300:

324:

VLAV TCAQE | GVIRVKPQVS | ESKL

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Identification of peroxisomal acyl-CoA thioesterases in yeast and humans."

(PMID: 10092594)

[2].

"Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation."

(PMID: 9153233)

[3].

"A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef."

(PMID: 9299485)

[4].

"Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs."

(PMID: 16940157)

[5].

"A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases."

(PMID: 16103133)

[6].

"The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes."

(PMID: 16141203)

[7].

"Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis."

(PMID: 15194431)

[8].

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."