Mouse Scd1/ Acyl-CoA desaturase 1 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Delta(9)-desaturase 1, Delta-9 desaturase 1, Fatty acid desaturase 1, Stearoyl-CoA desaturase 1

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse Acyl-CoA desaturase 1

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Mouse Scd1 ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

N/A

Function:

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:11500518, PubMed:11533264, PubMed:16275639, PubMed:16443825, PubMed:26098370). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:11500518, PubMed:11533264, PubMed:16443825, PubMed:26098370). Plays an important role in lipid biosynthesis (PubMed:17127673, PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:26098370). Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (PubMed:12177411, PubMed:17127673, PubMed:24356954, PubMed:24295027). Plays an important role in body energy homeostasis (PubMed:17127673, PubMed:15210843, PubMed:24295027, PubMed:24356954). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:15210843, PubMed:26098370). Required for normal development of sebaceous glands (PubMed:17738154, PubMed:11533264). Required for the biosynthesis of normal levels of delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland (PubMed:11500518). Required for normal production of meibum, an oily material that prevents drying of the cornea (PubMed:11533264).

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Microsome membrane

Database link

UniGene:

Mm.267377

SMR:

P13516

STRING:

10090.ENSMUSP00000036936

KEGG:

mmu:20249

Pfam: