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ACO1 (GeneName), Cytoplasmic aconitate hydratase (ProteinName), ACOC_HUMAN.

Product Name:

Human ACO1/ Cytoplasmic aconitate hydratase ELISA Kit

Cat.#:

E14200h

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, IREB1

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

1.56-100U/L

Sensitivity:

0.73U/L

Specificity:

Natural and recombinant human Cytoplasmic aconitate hydratase

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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Human ACO1 ELISA Kit

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Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Cytoplasmic aconitate hydratase and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	109-119%	103-111%	112-122%	101-111%
EDTA plasma(n=5)	89-89%	110-122%	81-90%	96-106%
heparin plasma(n=5)	100-110%	95-104%	101-113%	105-115%

General Annotation

Sub Unit:

Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).

Function:

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

Subcellular Location:

Cytoplasm

Database link

UniGene:

Hs.567229

SMR:

P21399

STRING:

9606.ENSP00000309477

KEGG:

hsa:48

MIM:

100880

Pfam:

PF00330

Uniprot:

P21399

Related Product

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Bovine ACO1 ELISA Kit

Chicken ACO1 ELISA Kit

Mouse Aco1 CLIA Kit

Sequence length:

889

Sequence:

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889:

VKLDTGKTFQ | AVMRFDTDVE | LTYFLNGGIL | NYMIRKMAK

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein."

(PMID: 2172968)

[2].

"Crystal structure of human iron regulatory protein 1 as cytosolic aconitase."

(PMID: 16407072)

[3].

"Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase."

(PMID: 1903202)

[4].

"Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins."

(PMID: 23891004)

[5].

"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

(PMID: 20877624)

[6].

"Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin."

(PMID: 20053667)

[7].

"Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations."

(PMID: 20574843)

[8].

"Control of iron homeostasis by an iron-regulated ubiquitin ligase."

(PMID: 19762596)

[9].

"An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis."

(PMID: 19762597)

[10].

"Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins."

(PMID: 17200797)

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