ACO1 (GeneName), Cytoplasmic aconitate hydratase (ProteinName), ACOC_HUMAN.
Product Name:
Human ACO1/ Cytoplasmic aconitate hydratase ELISA Kit
Cat.#:
E14200h
Brand:
EIAab®
Regulatory Status:
Alternative:
Aconitase, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, IREB1
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
1.56-100U/L
Sensitivity:
0.73U/L
Specificity:
Natural and recombinant human Cytoplasmic aconitate hydratase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:

Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Cytoplasmic aconitate hydratase and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
Sample |
1:2 |
1:4 |
1:8 |
1:16 |
serum(n=5) |
109-119% |
103-111% |
112-122% |
101-111% |
EDTA plasma(n=5) |
89-89% |
110-122% |
81-90% |
96-106% |
heparin plasma(n=5) |
100-110%
|
95-104% |
101-113% |
105-115% |
General Annotation
Sub Unit:
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
Function:
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Subcellular Location:
Cytoplasm
This product has not yet been referenced specifically in any publications.
[1].
"Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein."
[2].
"Crystal structure of human iron regulatory protein 1 as cytosolic aconitase."
[3].
"Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase."
[4].
"Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins."
[5].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[6].
"Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin."
[7].
"Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations."
[9].
"An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis."
[10].
"Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins."
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