ACOT13 (基因名), Acyl-coenzyme A thioesterase 13 (蛋白名), ACO13_HUMAN.
Human ACOT13/ Acyl-coenzyme A thioesterase 13 ELISA Kit
Acyl-CoA thioesterase 13, Thioesterase superfamily member 2, THEM2, HT012, PNAS-27
Natural and recombinant human Acyl-coenzyme A thioesterase 13
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.
Cytoplasm Cytosol Mitochondrion Nucleus Cytoplasm Cytoskeleton Spindle During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin.
"The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis."
"Crystal structure of human thioesterase superfamily member 2."
"Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs."
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"Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function."
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