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ACOT13 (GeneName), Acyl-coenzyme A thioesterase 13 (ProteinName), ACO13_HUMAN.
Product Name:

Human ACOT13/ Acyl-coenzyme A thioesterase 13 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Acyl-CoA thioesterase 13, Thioesterase superfamily member 2, THEM2, HT012, PNAS-27

Detection Method:
ELISA
Specificity:
Natural and recombinant human Acyl-coenzyme A thioesterase 13
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human ACOT13 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homotetramer.


Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.


Subcellular Location:
Cytoplasm Cytosol Mitochondrion Nucleus Cytoplasm Cytoskeleton Spindle During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin.


This product has not yet been referenced specifically in any publications.

[1].
"The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis."

[2].
"Crystal structure of human thioesterase superfamily member 2."

[3].
"Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"The DNA sequence and analysis of human chromosome 6."

[7].
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."

[8].
"RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination."

[9].
"Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children."

[10].
"Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function."
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