ACMSD (GeneName), 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ProteinName), ACMSD_PIG.
Product Name:
Pig ACMSD/ 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase ELISA Kit
Cat.#:
E15399p
Brand:
EIAab®
Regulatory Status:
Alternative:
Picolinate carboxylase
Detection Method:
ELISA
Specificity:
Natural and recombinant pig 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Monomer.
Function:
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Subcellular Location:
N/A
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis"."
[2].
"The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis."
[3].
"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies."
[4].
"Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism."
[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[6].
"Architecture of the human interactome defines protein communities and disease networks."
[7].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
[8].
"An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation."
[9].
"Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling."
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