ACMSD (GeneName), 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ProteinName), ACMSD_HUMAN.
Human ACMSD/ 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase ELISA Kit
Natural and recombinant human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
MKIDIHSHIL | PKEWPDLKKR | FGYGGWVQLQ | HHSKGEAKLL | KDGKVFRVVR |
ENCWDPEVRI | REMDQKGVTV | QALSTVPVMF | SYWAKPEDTL | NLCQLLNNDL |
ASTVVSYPRR | FVGLGTLPMQ | APELAVKEME | RCVKELGFPG | VQIGTHVNEW |
DLNAQELFPV | YAAAERLKCS | LFVHPWDMQM | DGRMAKYWLP | WLVGMPAETT |
IAICSMIMGG | VFEKFPKLKV | CFAHGGGAFP | FTVGRISHGF | SMRPDLCAQD |
NPMNPKKYLG | SFYTDALVHD | PLSLKLLTDV | IGKDKVILGT | DYPFPLGELE |
PGKLIESMEE | FDEETKNKLK | AGNALAFLGL | ERKQFE
This product has not yet been referenced specifically in any publications.
"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis"."
"The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis."
"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies."
"Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
"An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation."
"Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling."
"An atlas of genetic influences on human blood metabolites."
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