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ACMSD (GeneName), 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ProteinName), ACMSD_BOVIN.
Product Name:

Bovine ACMSD/ 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase ELISA Kit

Cat.#:

E15399b

Brand:
EIAab®
Regulatory Status:
Alternative:

Picolinate carboxylase

Detection Method:
ELISA
Specificity:
Natural and recombinant bovine 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Bovine ACMSD ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Monomer.


Function:
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.


Subcellular Location:
N/A


This product has not yet been referenced specifically in any publications.

[1].
"Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis"."

[2].
"The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis."

[3].
"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies."

[4].
"Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[8].
"An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation."

[9].
"Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling."

[10].
"An atlas of genetic influences on human blood metabolites."
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