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CHRM2 (GeneName), Muscarinic acetylcholine receptor M2 (ProteinName), ACM2_PIG.

Product Name:

Pig CHRM2/ Muscarinic acetylcholine receptor M2 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Detection Method:

ELISA

Specificity:

Natural and recombinant pig Muscarinic acetylcholine receptor M2

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Pig CHRM2 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Interacts with ARRB1 and ARRB2 (By similarity). Interacts with RACK1; the interaction regulates CHRM2 internalization.

Function:

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Phosphorylation in response to agonist binding promotes receptor internalization.

Database link

UniGene:

Ssc.16247

KEGG:

ssc:397498

Pfam:

PF00001

Uniprot:

P06199

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Sequence length:

466

Sequence:

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450:

466:

FKHLLMCHYK | NIGATR

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction."

(PMID: 19644963)

[2].

"No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples."

(PMID: 19418213)

[3].

"Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence."

(PMID: 17160701)

[4].

"Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins."

(PMID: 16181410)

[5].

"CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study."

(PMID: 16000316)

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