CHRM2 (GeneName), Muscarinic acetylcholine receptor M2 (ProteinName), ACM2_HUMAN.
Human CHRM2/ Muscarinic acetylcholine receptor M2 ELISA Kit
Natural and recombinant human Muscarinic acetylcholine receptor M2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Phosphorylation in response to agonist binding promotes receptor internalization.
MNNSTNSSNN | SLALTSPYKT | FEVVFIVLVA | GSLSLVTIIG | NILVMVSIKV |
NRHLQTVNNY | FLFSLACADL | IIGVFSMNLY | TLYTVIGYWP | LGPVVCDLWL |
ALDYVVSNAS | VMNLLIISFD | RYFCVTKPLT | YPVKRTTKMA | GMMIAAAWVL |
SFILWAPAIL | FWQFIVGVRT | VEDGECYIQF | FSNAAVTFGT | AIAAFYLPVI |
IMTVLYWHIS | RASKSRIKKD | KKEPVANQDP | VSPSLVQGRI | VKPNNNNMPS |
SDDGLEHNKI | QNGKAPRDPV | TENCVQGEEK | ESSNDSTSVS | AVASNMRDDE |
ITQDENTVST | SLGHSKDENS | KQTCIRIGTK | TPKSDSCTPT | NTTVEVVGSS |
GQNGDEKQNI | VARKIVKMTK | QPAKKKPPPS | REKKVTRTIL | AILLAFIITW |
APYNVMVLIN | TFCAPCIPNT | VWTIGYWLCY | INSTINPACY | ALCNATFKKT |
FKHLLMCHYK | NIGATR
This product has not yet been referenced specifically in any publications.
"Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction."
"No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples."
"Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence."
"Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins."
"CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study."
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