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CHRM2 (GeneName), Muscarinic acetylcholine receptor M2 (ProteinName), ACM2_BOVIN.
Product Name:

Bovine CHRM2/ Muscarinic acetylcholine receptor M2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Muscarinic acetylcholine receptor M2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Bovine CHRM2 ELISA Kit
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Bovine CHRM2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.


Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.


Subcellular Location:
Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Phosphorylation in response to agonist binding promotes receptor internalization.


This product has not yet been referenced specifically in any publications.

[1].
"Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction."

[2].
"No association between Cholinergic Muscarinic Receptor 2 (CHRM2) genetic variation and cognitive abilities in three independent samples."

[3].
"Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence."

[4].
"Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins."

[5].
"CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study."
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