Chrm1 (GeneName), Muscarinic acetylcholine receptor M1 (ProteinName), ACM1_RAT.
Rat Chrm1/ Muscarinic acetylcholine receptor M1 ELISA Kit
Natural and recombinant rat Muscarinic acetylcholine receptor M1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with GPRASP2.
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein
MNTSVPPAVS | PNITVLAPGK | GPWQVAFIGI | TTGLLSLATV | TGNLLVLISF |
KVNTELKTVN | NYFLLSLACA | DLIIGTFSMN | LYTTYLLMGH | WALGTLACDL |
WLALDYVASN | ASVMNLLLIS | FDRYFSVTRP | LSYRAKRTPR | RAALMIGLAW |
LVSFVLWAPA | ILFWQYLVGE | RTVLAGQCYI | QFLSQPIITF | GTAMAAFYLP |
VTVMCTLYWR | IYRETENRAR | ELAALQGSET | PGKGGGSSSS | SERSQPGAEG |
SPESPPGRCC | RCCRAPRLLQ | AYSWKEEEEE | DEGSMESLTS | SEGEEPGSEV |
VIKMPMVDSE | AQAPTKQPPK | SSPNTVKRPT | KKGRDRGGKG | QKPRGKEQLA |
KRKTFSLVKE | KKAARTLSAI | LLAFILTWTP | YNIMVLVSTF | CKDCVPETLW |
ELGYWLCYVN | STVNPMCYAL | CNKAFRDTFR | LLLLCRWDKR | RWRKIPKRPG |
This product has not yet been referenced specifically in any publications.
"Muscarinic acetylcholine receptor 1 gene polymorphisms associated with high myopia."
"Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence."
"Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects."
"Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells."
"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis."
"Genetical genomic determinants of alcohol consumption in rats and humans."
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