ACTL6B (GeneName), Actin-like protein 6B (ProteinName), ACL6B_HUMAN.
Human ACTL6B/ Actin-like protein 6B ELISA Kit
53 kDa BRG1-associated factor B, Actin-related protein Baf53b, ArpNalpha, BRG1-associated factor 53B, BAF53B, ACTL6, BAF53B
Natural and recombinant human Actin-like protein 6B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the bBAF complex, which includes at least actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57. Note that the bBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions. PBRM1 does not belong to bBAF complex. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.
MSGGVYGGDE | VGALVFDIGS | FSVRAGYAGE | DCPKADFPTT | VGLLAAEEGG |
GLELEGDKEK | KGKIFHIDTN | ALHVPRDGAE | VMSPLKNGMI | EDWECFRAIL |
DHTYSKHVKS | EPNLHPVLMS | EAPWNTRAKR | EKLTELMFEQ | YNIPAFFLCK |
TAVLTAFANG | RSTGLVLDSG | ATHTTAIPVH | DGYVLQQGIV | KSPLAGDFIS |
MQCRELFQEM | AIDIIPPYMI | AAKEPVREGA | PPNWKKKEKL | PQVSKSWHNY |
MCNEVIQDFQ | ASVLQVSDSP | YDEQVAAQMP | TVHYEMPNGY | NTDYGAERLR |
IPEGLFDPSN | VKGLSGNTML | GVGHVVTTSI | GMCDIDIRPG | LYGSVIVTGG |
NTLLQGFTDR | LNRELSQKTP | PSMRLKLIAS | NSTMERKFSP | WIGGSILASL |
GTFQQMWISK | QEYEEGGKQC | VERKCP
This product has not yet been referenced specifically in any publications.
"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Human chromosome 7: DNA sequence and biology."
"The DNA sequence of human chromosome 7."
"Identification of a polymorphic, neuron-specific chromatin remodeling complex."
"Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues."
"Architecture of the human interactome defines protein communities and disease networks."
"Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis."
"Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes."
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