ACTL6B (基因名), Actin-like protein 6B (蛋白名), ACL6B_HUMAN.
Human ACTL6B/ Actin-like protein 6B ELISA Kit
53 kDa BRG1-associated factor B, Actin-related protein Baf53b, ArpNalpha, BRG1-associated factor 53B, BAF53B, ACTL6, BAF53B
Natural and recombinant human Actin-like protein 6B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the bBAF complex, which includes at least actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57. Note that the bBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions. PBRM1 does not belong to bBAF complex. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.
MSGGVYGGDE | VGALVFDIGS | FSVRAGYAGE | DCPKADFPTT | VGLLAAEEGG |
GLELEGDKEK | KGKIFHIDTN | ALHVPRDGAE | VMSPLKNGMI | EDWECFRAIL |
DHTYSKHVKS | EPNLHPVLMS | EAPWNTRAKR | EKLTELMFEQ | YNIPAFFLCK |
TAVLTAFANG | RSTGLVLDSG | ATHTTAIPVH | DGYVLQQGIV | KSPLAGDFIS |
MQCRELFQEM | AIDIIPPYMI | AAKEPVREGA | PPNWKKKEKL | PQVSKSWHNY |
MCNEVIQDFQ | ASVLQVSDSP | YDEQVAAQMP | TVHYEMPNGY | NTDYGAERLR |
IPEGLFDPSN | VKGLSGNTML | GVGHVVTTSI | GMCDIDIRPG | LYGSVIVTGG |
NTLLQGFTDR | LNRELSQKTP | PSMRLKLIAS | NSTMERKFSP | WIGGSILASL |
GTFQQMWISK | QEYEEGGKQC | VERKCP
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