ACKR4 (基因名), Atypical chemokine receptor 4 (蛋白名), ACKR4_HUMAN.
Human ACKR4/ Atypical chemokine receptor 4 ELISA Kit
C-C chemokine receptor type 11, C-C CKR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR, CCBP2, CCR11, CCRL1, VSHK1
Natural and recombinant human Atypical chemokine receptor 4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
MALEQNQSTD | YYYEENEMNG | TYDYSQYELI | CIKEDVREFA | KVFLPVFLTI |
VFVIGLAGNS | MVVAIYAYYK | KQRTKTDVYI | LNLAVADLLL | LFTLPFWAVN |
AVHGWVLGKI | MCKITSALYT | LNFVSGMQFL | ACISIDRYVA | VTKVPSQSGV |
GKPCWIICFC | VWMAAILLSI | PQLVFYTVND | NARCIPIFPR | YLGTSMKALI |
QMLEICIGFV | VPFLIMGVCY | FITARTLMKM | PNIKISRPLK | VLLTVVIVFI |
VTQLPYNIVK | FCRAIDIIYS | LITSCNMSKR | MDIAIQVTES | IALFHSCLNP |
ILYVFMGASF | KNYVMKVAKK | YGSWRRQRQS | VEEFPFDSEG | PTEPTSTFSI |
"Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR."
"Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK."
"Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart."
"Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR."
"β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
"The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines."
"[AH8165, a new muscle relaxant]."
"Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells."
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