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首页  >  酶联免疫试剂盒  >  Human ACKR4 ELISA Kit
ACKR4 (基因名), Atypical chemokine receptor 4 (蛋白名), ACKR4_HUMAN.
产品名称:

Human ACKR4/ Atypical chemokine receptor 4 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

C-C chemokine receptor type 11, C-C CKR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR, CCBP2, CCR11, CCRL1, VSHK1

检测方法:
ELISA
特异性:
Natural and recombinant human Atypical chemokine receptor 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human ACKR4 ELISA Kit
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Human ACKR4 ELISA Kit
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产品说明书


通用注释


亚单元:
Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.


功能:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.


亚细胞位置:
Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.


该产品尚未在任何出版物中被引用。

[1].
"Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR."

[2].
"Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK."

[3].
"Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart."

[4].
"Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR."

[5].
"β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."

[6].
"The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines."

[9].
"[AH8165, a new muscle relaxant]."

[10].
"Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells."
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