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首页  >  酶联免疫试剂盒  >  Bovine ACKR4 ELISA Kit
ACKR4 (基因名), Atypical chemokine receptor 4 (蛋白名), ACKR4_BOVIN.
产品名称:

Bovine ACKR4/ Atypical chemokine receptor 4 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

C-C chemokine receptor type 11, C-C CKR-11, CC chemokine receptor-like 1, Protein PPR1, Putative gustatory receptor type B, CCR11, CCRL1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Atypical chemokine receptor 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine ACKR4 ELISA Kit
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Bovine ACKR4 ELISA Kit
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产品说明书


通用注释


亚单元:
Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.


功能:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.


亚细胞位置:
Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).


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