ACKR3 (GeneName), Atypical chemokine receptor 3 (ProteinName), ACKR3_HUMAN.
Human ACKR3/ Atypical chemokine receptor 3 ELISA Kit
C-X-C chemokine receptor type 7, CXC-R7, Chemokine orphan receptor 1, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, RDC-1, CMKOR1, CXCR7, GPR159, RDC1
Natural and recombinant human Atypical chemokine receptor 3
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Cell membrane Multi-pass membrane protein Cytoplasm Perinuclear region Early endosome Recycling endosome Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
MDLHLFDYSE | PGNFSDISWP | CNSSDCIVVD | TVMCPNMPNK | SVLLYTLSFI |
YIFIFVIGMI | ANSVVVWVNI | QAKTTGYDTH | CYILNLAIAD | LWVVLTIPVW |
VVSLVQHNQW | PMGELTCKVT | HLIFSINLFG | SIFFLTCMSV | DRYLSITYFT |
NTPSSRKKMV | RRVVCILVWL | LAFCVSLPDT | YYLKTVTSAS | NNETYCRSFY |
PEHSIKEWLI | GMELVSVVLG | FAVPFSIIAV | FYFLLARAIS | ASSDQEKHSS |
RKIIFSYVVV | FLVCWLPYHV | AVLLDIFSIL | HYIPFTCRLE | HALFTALHVT |
QCLSLVHCCV | NPVLYSFINR | NYRYELMKAF | IFKYSAKTGL | TKLIDASRVS |
ETEYSALEQS | TK
This product has not yet been referenced specifically in any publications.
"The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes."
"Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells."
"Ubiquitination of CXCR7 controls receptor trafficking."
"Carboxy-terminus of CXCR7 regulates receptor localization and function."
"CXCR7 protein expression in human adult brain and differentiated neurons."
"CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells."
"The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects."
"CXCR7 functions as a scavenger for CXCL12 and CXCL11."
"Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7."
"Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands."
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