ACKR3 (GeneName), Atypical chemokine receptor 3 (ProteinName), ACKR3_CANFA.
Product Name:
Dog ACKR3/ Atypical chemokine receptor 3 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
C-X-C chemokine receptor type 7, CXC-R7, Chemokine orphan receptor 1, G-protein coupled receptor RDC1, RDC-1, CMKOR1, CXCR7, RDC1
Detection Method:
ELISA
Specificity:
Natural and recombinant dog Atypical chemokine receptor 3
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
- Feedback Wall (0)
General Annotation
Sub Unit:
Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity (By similarity). Interacts with ARRB1 and ARRB2.
Function:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cytoplasm
Perinuclear region
Early endosome
Recycling endosome
Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes."
[2].
"Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells."
[6].
"CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells."
[7].
"The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects."
[9].
"Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7."
[10].
"Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands."
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