ACKR2 (基因名), Atypical chemokine receptor 2 (蛋白名), ACKR2_HUMAN.
Human ACKR2/ Atypical chemokine receptor 2 ELISA Kit
C-C chemokine receptor D6, Chemokine receptor CCR-10, Chemokine receptor CCR-9, Chemokine-binding protein 2, Chemokine-binding protein D6, CCBP2, CCR10, CMKBR9, D6
Natural and recombinant human Atypical chemokine receptor 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
MAATASPQPL | ATEDADSENS | SFYYYDYLDE | VAFMLCRKDA | VVSFGKVFLP |
VFYSLIFVLG | LSGNLLLLMV | LLRYVPRRRM | VEIYLLNLAI | SNLLFLVTLP |
FWGISVAWHW | VFGSFLCKMV | STLYTINFYS | GIFFISCMSL | DKYLEIVHAQ |
PYHRLRTRAK | SLLLATIVWA | VSLAVSIPDM | VFVQTHENPK | GVWNCHADFG |
GHGTIWKLFL | RFQQNLLGFL | LPLLAMIFFY | SRIGCVLVRL | RPAGQGRALK |
IAAALVVAFF | VLWFPYNLTL | FLHTLLDLQV | FGNCEVSQHL | DYALQVTESI |
AFLHCCFSPI | LYAFSSHRFR | QYLKAFLAAV | LGWHLAPGTA | QASLSSCSES |
SILTAQEEMT | GMNDLGERQS | ENYPNKEDVG | NKSA
"The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors."
"Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3."
"Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6."
"Review: Structure-function and biological properties of the atypical chemokine receptor D6."
"An analysis of the function and expression of D6 on lymphatic endothelial cells."
"β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
"Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C."
"Multiple roles for the C-terminal tail of the chemokine scavenger D6."
"Chemokine decoy receptor d6 plays a negative role in human breast cancer."
"The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes."
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