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首页  >  酶联免疫试剂盒  >  Mouse Ackr1 ELISA Kit
Ackr1 (基因名), Atypical chemokine receptor 1 (蛋白名), ACKR1_MOUSE.
产品名称:

Mouse Ackr1/ Atypical chemokine receptor 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Duffy antigen/chemokine receptor, CD234, Darc, Dfy, Fy

检测方法:
ELISA
特异性:
Natural and recombinant mouse Atypical chemokine receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Ackr1 ELISA Kit
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产品说明书


通用注释


亚单元:
N/A


功能:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.


亚细胞位置:
Early endosome Recycling endosome Membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite."

[2].
"Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites."

[3].
"Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals."

[4].
"Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals."

[5].
"Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue."

[6].
"FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil."

[7].
"Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells: role of the Duffy antigen receptor for chemokines."

[8].
"Shedding light on DARC: the role of the Duffy antigen/receptor for chemokines in inflammation, infection and malignancy."

[9].
"The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization."

[10].
"Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease."
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