ACKR1 (基因名), Atypical chemokine receptor 1 (蛋白名), ACKR1_HUMAN.
Human ACKR1/ Atypical chemokine receptor 1 ELISA Kit
Duffy antigen/chemokine receptor, Fy glycoprotein, Glycoprotein D, Plasmodium vivax receptor, GpFy, CD234, DARC, FY, GPD
Natural and recombinant human Atypical chemokine receptor 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Early endosome Recycling endosome Membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
MGNCLHRAEL | SPSTENSSQL | DFEDVWNSSY | GVNDSFPDGD | YGANLEAAAP |
CHSCNLLDDS | ALPFFILTSV | LGILASSTVL | FMLFRPLFRW | QLCPGWPVLA |
QLAVGSALFS | IVVPVLAPGL | GSTRSSALCS | LGYCVWYGSA | FAQALLLGCH |
ASLGHRLGAG | QVPGLTLGLT | VGIWGVAALL | TLPVTLASGA | SGGLCTLIYS |
TELKALQATH | TVACLAIFVL | LPLGLFGAKG | LKKALGMGPG | PWMNILWAWF |
IFWWPHGVVL | GLDFLVRSKL | LLLSTCLAQQ | ALDLLLNLAE | ALAILHCVAT |
PLLLALFCHQ | ATRTLLPSLP | LPEGWSSHLD | TLGSKS
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