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首页  >  酶联免疫试剂盒  >  Human ACKR1 ELISA Kit
ACKR1 (基因名), Atypical chemokine receptor 1 (蛋白名), ACKR1_HUMAN.
产品名称:

Human ACKR1/ Atypical chemokine receptor 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, Plasmodium vivax receptor, CD234, DARC, FY, GPD

检测方法:
ELISA
特异性:
Natural and recombinant human Atypical chemokine receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human ACKR1 ELISA Kit
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Human ACKR1 ELISA Kit
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产品说明书


通用注释


亚单元:
N/A


功能:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.


亚细胞位置:
Early endosome Recycling endosome Membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.


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