Tnk2 (基因名), Activated CDC42 kinase 1 (蛋白名), ACK1_RAT.
Rat Tnk2/ Activated CDC42 kinase 1 ELISA Kit
ACK-1, Tyrosine kinase non-receptor protein 2, Ack1
Natural and recombinant rat Activated CDC42 kinase 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. Interacts with CDC42. Interacts with CSPG4 (activated). Interacts with MERTK (activated); stimulates autophosphorylation. May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1. Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Interacts with EGFR, and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with BCAR1/p130cas via SH3 domains. Forms complexes with GRB2 and numerous receptor tyrosine kinases (RTK) including LTK, AXL or PDGFRL, in which GRB2 promotes RTK recruitment by TNK2. Interacts with NEDD4 (via WW3 domain). NEDD4L and EGF promote association with NEDD4.
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363', thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Cell membrane Nucleus Endosome Cell junction Adherens junction Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle Clathrin-coated vesicle Membrane Clathrin-coated pit The Tyr-284 phosphorylated form is found in both the membrane and nucleus. Colocalizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent (By similarity).
MQPEEGTGWL | LELLSEVQLQ | QYFLRLRDDL | NITRLSHFEY | VKNEDLEKIG |
MGRPGQRRLW | EAVKRRKAMC | KRKSWMSKVF | SGKRQEAEFP | SHHSQSTFRK |
PSPTPGGLAG | EGTLQSLTCL | IGEKDLRLLE | KLGDGSFGVV | RRGEWDAPAG |
KTVSVAVKCL | KPDVLSQPEA | MDDFIREVNA | MHSLDHRNLI | RLYGVVLTPP |
MKMVTELAPL | GSLLDRLRKH | QGHFLLGTLS | RYAVQVAEGM | GYLESKRFIH |
RDLAARNLLL | ATRDLVKIGD | FGLMRALPQN | DGHYVMQEHR | KVPFAWCAPE |
SLKTRTFSHA | SDTWMFGVTL | WEMFTYGQEP | WIGLNGSQIL | HKIDKEGERL |
PRPEDCPQDI | YNVMVQCWAH | KPEDRPTFVA | LRDFLLEAQP | TDMRALQDFE |
EPDKLHIQMN | DVITVIEGRA | ENYWWRGQNT | RTLCVGPFPR | NVVTSVAGLS |
AQDISQPLQN | SFIHTGHGDS | DPRHCWGFPD | RIDELYLGNP | MDPPDLLSVE |
LSTSRPTQHL | GRMKKPTYDP | VSEDPDPLSS | DFKRLGLRKP | ALPRGLWLAK |
PSARVPGTKA | GRSSGGEVTL | IDFGEEPVAP | TPRPCAPSLA | QLAMDACSLL |
DKTPPQSPTR | ALPRPLHPTP | VVDWDARPLP | PPPAYDDVAQ | DEDDFEVCSI |
NSTLVSAGLP | TGPSQGETNY | AFVPEQAQLP | PALEDNLFLP | PQGGGQPPSS |
AQTAEIFQAL | QQECMRQLQV | PTGQLTPSPT | PGGDDKPQVP | PRVPIPPRPT |
RPRVGLSPAP | LGEEEASRWP | GPSSPPRVPP | REPLSPQGSR | TPSPLVPPGS |
SPLPHRLSSS | PGKTMPTTQS | FASDPKYATP | QVIQAPGPRA | GPCILPIVRD |
GRKVSSTHYY | LLPERPPYLE | RYQRFLREAQ | SPEEPAALPV | PPLLPPPSTP |
APAAPTATVR | PMPQAAPDPK | ANFSTNNSNP | GAQPPSLRAS | ARLPQRGCPG |
DGQEAARPAD | KVQMLQAMVH | GVTTEECQAA | LRSHSWSIQR | AAQYLKVEQL |
FGLGLRPRVE | CHKVLEMFDW | NLEQAGCHLL | GSCGPAHHKR |
"Shepherding AKT and androgen receptor by Ack1 tyrosine kinase."
"Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2."
"Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."
"Dysregulation of Ack1 inhibits down-regulation of the EGF receptor."
"Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation."
"Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox."
"SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1."
"Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1."
"Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase."
"Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK."
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