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Chrng (GeneName), Acetylcholine receptor subunit gamma (ProteinName), ACHG_RAT.

Product Name:

Rat Chrng/ Acetylcholine receptor subunit gamma ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Achrg

Detection Method:

ELISA

Specificity:

Natural and recombinant rat Acetylcholine receptor subunit gamma

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Rat Chrng ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Rn.44634

STRING:

10116.ENSRNOP00000026529

KEGG:

rno:25753

Pfam:

PF02931

Uniprot:

P18916

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Sequence length:

519

Sequence:

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450:

500:

519:

QVPDLPFPGD | PRPYLPLPD

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Escobar syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit."

(PMID: 16826520)

[2].

"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

(PMID: 20584212)

[3].

"A large-scale candidate gene association study of age at menarche and age at natural menopause."

(PMID: 20734064)

[4].

"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."

(PMID: 19086053)

[5].

"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."

(PMID: 19259974)

[6].

"Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study."

(PMID: 18625075)

[7].

"Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome."

(PMID: 16826531)

[8].

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."

(PMID: 15815621)

[9].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."

(PMID: 14702039)

[10].

"Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits."