CHRNG (GeneName), Acetylcholine receptor subunit gamma (ProteinName), ACHG_HUMAN.
Human CHRNG/ Acetylcholine receptor subunit gamma ELISA Kit
Natural and recombinant human Acetylcholine receptor subunit gamma
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MHGGQGPLLL | LLLLAVCLGA | QGRNQEERLL | ADLMQNYDPN | LRPAERDSDV |
VNVSLKLTLT | NLISLNEREE | ALTTNVWIEM | QWCDYRLRWD | PRDYEGLWVL |
RVPSTMVWRP | DIVLENNVDG | VFEVALYCNV | LVSPDGCIYW | LPPAIFRSAC |
SISVTYFPFD | WQNCSLIFQS | QTYSTNEIDL | QLSQEDGQTI | EWIFIDPEAF |
TENGEWAIQH | RPAKMLLDPA | APAQEAGHQK | VVFYLLIQRK | PLFYVINIIA |
PCVLISSVAI | LIHFLPAKAG | GQKCTVAINV | LLAQTVFLFL | VAKKVPETSQ |
AVPLISKYLT | FLLVVTILIV | VNAVVVLNVS | LRSPHTHSMA | RGVRKVFLRL |
LPQLLRMHVR | PLAPAAVQDT | QSRLQNGSSG | WSITTGEEVA | LCLPRSELLF |
QQWQRQGLVA | AALEKLEKGP | ELGLSQFCGS | LKQAAPAIQA | CVEACNLIAC |
ARHQQSHFDN | GNEEWFLVGR | VLDRVCFLAM | LSLFICGTAG | IFLMAHYNRV |
PALPFPGDPR | PYLPSPD
This product has not yet been referenced specifically in any publications.
"Escobar syndrome is a prenatal myasthenia caused by disruption of the acetylcholine receptor fetal gamma subunit."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study."
"Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome."
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits."
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