CHRNE (GeneName), Acetylcholine receptor subunit epsilon (ProteinName), ACHE_BOVIN.
Bovine CHRNE/ Acetylcholine receptor subunit epsilon ELISA Kit
Natural and recombinant bovine Acetylcholine receptor subunit epsilon
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MAGALLCALL | LLQLLGRGEG | KNEELRLYHY | LFDTYDPGRR | PVQEPEDTVT |
ISLKVTLTNL | ISLNEKEETL | TTSVWIGIDW | QDYRLNYSKG | DFGGVETLRV |
PSELVWLPEI | VLENNIDGQF | GVAYEANVLV | SEGGYLSWLP | PAIYRSTCAV |
EVTYFPFDWQ | NCSLVFRSQT | YNAEEVEFVF | AVDDEGKTIS | KIDIDTEAYT |
ENGEWAIDFC | PGVIRRHDGD | SAGGPGETDV | IYSLIIRRKP | LFYVINIIVP |
CVLISGLVLL | AYFLPAQAGG | QKCTVSINVL | LAQTVFLFLI | AQKTPETSLS |
VPLLGRYLIF | VMVVATLIVM | NCVIVLNVSL | RTPTTHAMSP | RLRYVLLELL |
PQLLGSGAPP | EIPRAASPPR | RASSLGLLLR | AEELILKKPR | SELVFEQQRH |
RHGTWTATLC | QNLGAAAPEI | RCCVDAVNFV | ASSTRDQEAT | GEEVSDWVRM |
GKALDSICFW | AALVLFLVGS | SLIFLGAYFN | RVPQLPYPPC | M
This product has not yet been referenced specifically in any publications.
"Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits."
"Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"The CHRNE 1293insG founder mutation is a frequent cause of congenital myasthenia in North Africa."
"Lack of association between acetylcholine receptor epsilon polymorphisms and early-onset myasthenia gravis."
"Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome."
"Immature end-plates and utrophin deficiency in congenital myasthenic syndrome caused by epsilon-AChR subunit truncating mutations."
"Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations."
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