CHRNE (GeneName), Acetylcholine receptor subunit epsilon (ProteinName), ACHE_BOVIN.
Product Name:
Bovine CHRNE/ Acetylcholine receptor subunit epsilon ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant bovine Acetylcholine receptor subunit epsilon
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits."
[2].
"Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating."
[3].
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
[4].
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
[5].
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
[6].
"The CHRNE 1293insG founder mutation is a frequent cause of congenital myasthenia in North Africa."
[7].
"Lack of association between acetylcholine receptor epsilon polymorphisms and early-onset myasthenia gravis."
[8].
"Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome."
[9].
"Immature end-plates and utrophin deficiency in congenital myasthenic syndrome caused by epsilon-AChR subunit truncating mutations."
[10].
"Congenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutations."
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