Chrnd (GeneName), Acetylcholine receptor subunit delta (ProteinName), ACHD_MOUSE.
Mouse Chrnd/ Acetylcholine receptor subunit delta ELISA Kit
Natural and recombinant mouse Acetylcholine receptor subunit delta
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MAGPVLTLGL | LAALVVCALP | GSWGLNEEQR | LIQHLFNEKG | YDKDLRPVAR |
KEDKVDVALS | LTLSNLISLK | EVEETLTTNV | WIDHAWVDSR | LQWDANDFGN |
ITVLRLPPDM | VWLPEIVLEN | NNDGSFQISY | ACNVLVYDSG | YVTWLPPAIF |
RSSCPISVTY | FPFDWQNCSL | KFSSLKYTAK | EITLSLKQEE | ENNRSYPIEW |
IIIDPEGFTE | NGEWEIVHRA | AKLNVDPSVP | MDSTNHQDVT | FYLIIRRKPL |
FYIINILVPC | VLISFMINLV | FYLPGDCGEK | TSVAISVLLA | QSVFLLLISK |
RLPATSMAIP | LVGKFLLFGM | VLVTMVVVIC | VIVLNIHFRT | PSTHVLSEGV |
KKFFLETLPK | LLHMSRPAEE | DPGPRALIRR | SSSLGYICKA | EEYFSLKSRS |
DLMFEKQSER | HGLARRLTTA | RRPPASSEQV | QQELFNEMKP | AVDGANFIVN |
HMRDQNSYNE | EKDNWNQVAR | TVDRLCLFVV | TPVMVVGTAW | IFLQGVYNQP |
PLQPFPGDPF | SYSEQDKRFI |
This product has not yet been referenced specifically in any publications.
"Association of the gene encoding the delta-subunit of the muscle acetylcholine receptor (CHRND) with acquired autoimmune myasthenia gravis."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders."
"Congenital myasthenia-related AChR delta subunit mutation interferes with intersubunit communication essential for channel gating."
"Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study."
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