CHRNB1 (GeneName), Acetylcholine receptor subunit beta (ProteinName), ACHB_HUMAN.
Human CHRNB1/ Acetylcholine receptor subunit beta ELISA Kit
Natural and recombinant human Acetylcholine receptor subunit beta
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MTPGALLMLL | GALGAPLAPG | VRGSEAEGRL | REKLFSGYDS | SVRPAREVGD |
RVRVSVGLIL | AQLISLNEKD | EEMSTKVYLD | LEWTDYRLSW | DPAEHDGIDS |
LRITAESVWL | PDVVLLNNND | GNFDVALDIS | VVVSSDGSVR | WQPPGIYRSS |
CSIQVTYFPF | DWQNCTMVFS | SYSYDSSEVS | LQTGLGPDGQ | GHQEIHIHEG |
TFIENGQWEI | IHKPSRLIQP | PGDPRGGREG | QRQEVIFYLI | IRRKPLFYLV |
NVIAPCILIT | LLAIFVFYLP | PDAGEKMGLS | IFALLTLTVF | LLLLADKVPE |
TSLSVPIIIK | YLMFTMVLVT | FSVILSVVVL | NLHHRSPHTH | QMPLWVRQIF |
IHKLPLYLRL | KRPKPERDLM | PEPPHCSSPG | SGWGRGTDEY | FIRKPPSDFL |
FPKPNRFQPE | LSAPDLRRFI | DGPNRAVALL | PELREVVSSI | SYIARQLQEQ |
EDHDALKEDW | QFVAMVVDRL | FLWTFIIFTS | VGTLVIFLDA | TYHLPPPDPF |
This product has not yet been referenced specifically in any publications.
"Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence."
"Mutations Causing Slow-Channel Myasthenia Reveal That a Valine Ring in the Channel Pore of Muscle AChR is Optimized for Stabilizing Channel Gating."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstr?m test for nicotine dependence."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population."
"No evidence for association between 19 cholinergic genes and bipolar disorder."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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