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Chrnb4 (GeneName), Neuronal acetylcholine receptor subunit beta-4 (ProteinName), ACHB4_MOUSE.

Product Name:

Mouse Chrnb4/ Neuronal acetylcholine receptor subunit beta-4 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Acrb4

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse Neuronal acetylcholine receptor subunit beta-4

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Mouse Chrnb4 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Mm.32694

SMR:

Q8R493

STRING:

10090.ENSMUSP00000034854

KEGG:

mmu:108015

Pfam:

PF02931

Uniprot:

Q8R493

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Sequence length:

495

Sequence:

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450:

495:

IEDWKFVAMV | VDRLFLWVFV | IVCILGTMGL | FLPPLFQIHA | PSKGL

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

(PMID: 19628475)

[2].

"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."

(PMID: 11742001)

[3].

"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

(PMID: 27344019)

[4].

"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."

(PMID: 21658281)

[5].

"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

(PMID: 19859904)

[6].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."