Chrnb4 (GeneName), Neuronal acetylcholine receptor subunit beta-4 (ProteinName), ACHB4_MOUSE.
Product Name:
Mouse Chrnb4/ Neuronal acetylcholine receptor subunit beta-4 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Acrb4
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Neuronal acetylcholine receptor subunit beta-4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
This product has not yet been referenced specifically in any publications.
[1].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
[2].
"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."
[4].
"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."
[5].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
[6].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
[7].
"Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes."
[8].
"Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study."
[9].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
[10].
"Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans."
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