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CHRNB4 (GeneName), Neuronal acetylcholine receptor subunit beta-4 (ProteinName), ACHB4_HUMAN.
Product Name:

Human CHRNB4/ Neuronal acetylcholine receptor subunit beta-4 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant human Neuronal acetylcholine receptor subunit beta-4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Human CHRNB4 ELISA Kit
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Human CHRNB4 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.


Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


Subcellular Location:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

[2].
"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."

[3].
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

[4].
"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."

[5].
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

[6].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

[7].
"Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes."

[8].
"Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study."

[9].
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."

[10].
"Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans."
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