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CHRNB4 (GeneName), Neuronal acetylcholine receptor subunit beta-4 (ProteinName), ACHB4_CHICK.

Product Name:

Chicken CHRNB4/ Neuronal acetylcholine receptor subunit beta-4 ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Neuronal acetylcholine receptor non-alpha-3 chain, N-alpha 3

Detection Method:

ELISA

Specificity:

Natural and recombinant chicken Neuronal acetylcholine receptor subunit beta-4

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Neurosciences

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Chicken CHRNB4 ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Gga.341

SMR:

P26153

STRING:

9031.ENSGALP00000004740

Pfam:

PF02931

Uniprot:

P26153

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Sequence length:

470

Sequence:

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470:

GTVGLFLQPL | FQNHIAATNP |

3D Model:

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."

(PMID: 19628475)

[2].

"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."

(PMID: 11742001)

[3].

"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."

(PMID: 27344019)

[4].

"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."

(PMID: 21658281)

[5].

"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."

(PMID: 19859904)

[6].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."