CHRNB4 (GeneName), Neuronal acetylcholine receptor subunit beta-4 (ProteinName), ACHB4_BOVIN.
Bovine CHRNB4/ Neuronal acetylcholine receptor subunit beta-4 ELISA Kit
Natural and recombinant bovine Neuronal acetylcholine receptor subunit beta-4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MRSALPLVLF | SLVALCGRGD | CRVANAEEKL | MDDLLNKTRY | NNLIRPATSS |
SQLISIQLQL | SLAQLISVNE | REQIMTTNIW | LKQEWTDYRL | AWNSSRYEGV |
NILRIPANRV | WLPDIVLYNN | ADGSYEVSLY | TNVVVRSNGS | VMWLPPAICK |
SACKIEVKHF | PFDQQNCTLK | FRSWTYDHTE | IDMVLKMPTA | SMDDFTPSGE |
WDIVALPGRR | TVNPQDPSYV | DVTYDFIIKR | KPLFYTINLI | IPCVLITSLA |
ILVFYLPSDC | GEKMTLCISV | LLALTVFLLL | ISKIVPPTSL | NVPLIGKYLM |
FTMVLVTFSI | VTSVCVLNVH | HRSPSTHTMA | PWVKRCFLHK | LPTFLFIKRP |
RQQPSRAPQS | SLARLTKSEA | TTTTTLAMGP | TSSSNLYGNS | MYFVNPGLAA |
PKSPVASDSA | GIPRDFRLRS | SGRFRQDVQE | ALEGVSFIAQ | HMKSDDLDQS |
VIEDWKYVAM | VVDRLFLWVF | VVVCVLGTVG | LFLPPLFQTH | TPSEEP
This product has not yet been referenced specifically in any publications.
"Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis."
"Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."
"Functional interaction between Lypd6 and nicotinic acetylcholine receptors."
"GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease."
"Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes."
"Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study."
"Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans."
"Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans."
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