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Chrnb2 (基因名), Neuronal acetylcholine receptor subunit beta-2 (蛋白名), ACHB2_RAT.
产品名称:

Rat Chrnb2/ Neuronal acetylcholine receptor subunit beta-2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Neuronal acetylcholine receptor non-alpha-1 chain, N-alpha 1, Acrb2

检测方法:
ELISA
特异性:
Natural and recombinant rat Neuronal acetylcholine receptor subunit beta-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Rat Chrnb2 ELISA Kit
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Rat Chrnb2 ELISA Kit
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通用注释


亚单元:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Alpha-2/4:beta-2 nAChR complexes are proposed to exist in two subtypes: LS (low agonist sensitivity) with a (alpha-2/4)3:(beta-2)2 and HS (high agonist sensitivity) with a (alpha-2/4)2:(beta-2)3 stoichiometry; the subtypes differ in their subunit binding interfaces which are involved in ligand binding. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6. The pentamer alpha3-beta-2 interacts with the conotoxin BuIA and the conotoxin MII (PubMed:16964981).


功能:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein


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