CHRNA1 (GeneName), Acetylcholine receptor subunit alpha (ProteinName), ACHA_HUMAN.
Human CHRNA1/ Acetylcholine receptor subunit alpha ELISA Kit
Natural and recombinant human Acetylcholine receptor subunit alpha
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MEPWPLLLLF | SLCSAGLVLG | SEHETRLVAK | LFKDYSSVVR | PVEDHRQVVE |
VTVGLQLIQL | INVDEVNQIV | TTNVRLKQGD | MVDLPRPSCV | TLGVPLFSHL |
QNEQWVDYNL | KWNPDDYGGV | KKIHIPSEKI | WRPDLVLYNN | ADGDFAIVKF |
TKVLLQYTGH | ITWTPPAIFK | SYCEIIVTHF | PFDEQNCSMK | LGTWTYDGSV |
VAINPESDQP | DLSNFMESGE | WVIKESRGWK | HSVTYSCCPD | TPYLDITYHF |
VMQRLPLYFI | VNVIIPCLLF | SFLTGLVFYL | PTDSGEKMTL | SISVLLSLTV |
FLLVIVELIP | STSSAVPLIG | KYMLFTMVFV | IASIIITVIV | INTHHRSPST |
HVMPNWVRKV | FIDTIPNIMF | FSTMKRPSRE | KQDKKIFTED | IDISDISGKP |
GPPPMGFHSP | LIKHPEVKSA | IEGIKYIAET | MKSDQESNNA | AAEWKYVAMV |
MDHILLGVFM | LVCIIGTLAV | FAGRLIELNQ | QG
This product has not yet been referenced specifically in any publications.
"Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues."
"The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon."
"Association of CHRN genes with "dizziness" to tobacco."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment."
"Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
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