Chrna9 (基因名), Neuronal acetylcholine receptor subunit alpha-9 (蛋白名), ACHA9_RAT.
Rat Chrna9/ Neuronal acetylcholine receptor subunit alpha-9 ELISA Kit
Nicotinic acetylcholine receptor subunit alpha-9, NACHR alpha-9, Acra9
Natural and recombinant rat Neuronal acetylcholine receptor subunit alpha-9
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Can form homo- or heterooligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the alpha-conotoxin RgIA (PubMed:25740413).
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MNRPHSCLSF | CWMYFAASGI | RAVETANGKY | AQKLFSDLFE | DYSSALRPVE |
DTDAVLNVTL | QVTLSQIKDM | DERNQILTAY | LWIRQTWHDA | YLTWDRDQYD |
RLDSIRIPSD | LVWRPDIVLY | NKADDESSEP | VNTNVVLRYD | GLITWDSPAI |
TKSSCVVDVT | YFPFDSQQCN | LTFGSWTYNG | NQVDIFNALD | SGDLSDFIED |
VEWEVHGMPA | VKNVISYGCC | SEPYPDVTFT | LLLKRRSSFY | IVNLLIPCVL |
ISFLAPLSFY | LPAASGEKVS | LGVTILLAMT | VFQLMVAEIM | PASENVPLIG |
KYYIATMALI | TASTALTIMV | MNIHFCGAEA | RPVPHWAKVV | ILKYMSRILF |
VYDVGESCLS | PRHSQEPEQV | TKVYSKLPES | NLKTSRNKDL | SRKKEVRKLL |
KNDLGYQGGI | PQNTDSYCAR | YEALTKNIEY | IAKCLKDHKA | TNSKGSEWKK |
VAKVIDRFFM | WIFFAMVFVM | TVLIIARAD
"Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function."
"A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
"Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene."
"Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain."
"Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA."
"A large-scale candidate gene association study of age at menarche and age at natural menopause."
"Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis."
"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes."
"No evidence for association between 19 cholinergic genes and bipolar disorder."
"Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes."
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